The superbug is here.

We’re creating programmable therapies to protect the world against the coming threat of antimicrobial resistance.

Why does it matter?
In collaboration with
Yale UniversityBerkley University of CaliforniaUCSFStanford University

Meet the enemy

Antibiotic resistant bacteria (AMR)

Instead of being killed by antibiotics, these bacteria have evolved the ability to survive and thrive in their presence. Antibiotic resistant infections are challenging due to limited treatment options. The World Health Organization deems these infections one of the top 10 global public health threats facing humanity.

Learn about our platform and our first clinical prototype. This is Felix's phage-based therapy that's already been effective in treating Pseudomonas aeruginosa infections in cystic fibrosis

Felix Platform
Antimicrobial resistance (AMR) is an

$80 trillion existential threat

The World Health Organization estimates

AMR will kill 1,270,000 people this year.

it's estimated that

by 2050 AMR will kill 10,000,000 people.

To put that in perspective:

That's a New York City full of people dying – every year

How do you defeat it?

1

Antimicrobial resistance is an evolutionary problem. We need an evolutionary approach to solve it.

When bacteria are exposed to antibiotics, they can acquire new features that help them to survive in the face of those antibiotics. An effective therapeutic alternative to antibiotics needs to target these resistance-conferring features.

Normal Bacteria
Antibiotics pass through the cell membrane and are toxic to the bacteria.
Antimicrobal Resistance
The bacteria acquires genetic changes that reduce the overall toxicity of the antibiotic.
2

Phages are programmable, safe, targeted, and powerful.

Phages are highly selective and thus can be targeted to only kill bad bacteria — leaving the good bacteria alone. This precision is at the core of Felix’s phage engineering platform, which is able to harness the power of a phage with the accuracy of a sniper rifle.

Natural Phage
A naturally occurring virus that targets and kills natural strains of bacteria.
Programmed Phage
An engineered virus, designed to specifically target adaptations of antimicrobial resistant bacteria.
3

Our platform harnesses the power of phages to make programmable therapies.

Our platform makes it possible to program phage to outsmart bacterial evolution. We harness machine learning to design phage characteristics targeting the specific features that contribute to their lethality. This makes our phages an ‘intelligent’ tool to combat emergent antimicrobial resistance.

Programmed Phage Attack
An engineered virus targeting adaptations conferring resistance.
Superbugs destroyed
The phage attack disables antibiotic resistance or kills the bacteria.

Ready to join the team?

We’re building a technical team of scientists and engineers who are passionate about working on world-saving problems.

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